ClinVar Miner

Submissions for variant NM_000455.4(STK11):c.1008T>C (p.Thr336=) (rs878853981)

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Total submissions: 4
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Invitae RCV000231458 SCV000284837 likely benign not provided 2018-09-20 criteria provided, single submitter clinical testing
GeneDx RCV000436493 SCV000514803 likely benign not specified 2016-05-31 criteria provided, single submitter clinical testing This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
Ambry Genetics RCV000563230 SCV000672314 likely benign Hereditary cancer-predisposing syndrome 2017-01-18 criteria provided, single submitter clinical testing Lines of evidence used in support of classification: Synonymous alterations with insufficient evidence to classify as benign
Color RCV000563230 SCV000691460 likely benign Hereditary cancer-predisposing syndrome 2017-09-24 criteria provided, single submitter clinical testing

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