ClinVar Miner

Submissions for variant NM_000455.4(STK11):c.672T>A (p.Ile224=) (rs1230000936)

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Total submissions: 4
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Invitae RCV000535362 SCV000629137 likely benign Peutz-Jeghers syndrome 2017-10-02 criteria provided, single submitter clinical testing
Ambry Genetics RCV000567034 SCV000672329 likely benign Hereditary cancer-predisposing syndrome 2016-03-09 criteria provided, single submitter clinical testing Lines of evidence used in support of classification: Synonymous alterations with insufficient evidence to classify as benign
Color RCV000567034 SCV000904359 likely benign Hereditary cancer-predisposing syndrome 2018-01-25 criteria provided, single submitter clinical testing
GeneDx RCV000842429 SCV000984449 likely benign not provided 2018-04-20 criteria provided, single submitter clinical testing This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.

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