Total submissions: 2
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
Labcorp Genetics |
RCV001851931 | SCV002230784 | pathogenic | not provided | 2021-11-30 | criteria provided, single submitter | clinical testing | For these reasons, this variant has been classified as Pathogenic. This sequence change replaces glycine, which is neutral and non-polar, with glutamic acid, which is acidic and polar, at codon 595 of the COL10A1 protein (p.Gly595Glu). This variant is not present in population databases (gnomAD no frequency). This missense change has been observed in individual(s) with metaphyseal chondrodysplasia, Schmid type (PMID: 7607655). It has also been observed to segregate with disease in related individuals. ClinVar contains an entry for this variant (Variation ID: 17479). Algorithms developed to predict the effect of missense changes on protein structure and function are either unavailable or do not agree on the potential impact of this missense change (SIFT: "Deleterious"; PolyPhen-2: "Probably Damaging"; Align-GVGD: "Class C0"). This variant disrupts the p.Gly595 amino acid residue in COL10A1. Other variant(s) that disrupt this residue have been determined to be pathogenic (PMID: 10721676, 15880705, 16088909; Invitae). This suggests that this residue is clinically significant, and that variants that disrupt this residue are likely to be disease-causing. |
OMIM | RCV000019031 | SCV000039318 | pathogenic | Metaphyseal chondrodysplasia, Schmid type | 1998-12-01 | no assertion criteria provided | literature only |