ClinVar Miner

Submissions for variant NM_000546.5(TP53):c.558T>C (p.Asp186=) (rs375275361)

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Total submissions: 3
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Ambry Genetics RCV000163164 SCV000213682 likely benign Hereditary cancer-predisposing syndrome 2015-03-24 criteria provided, single submitter clinical testing Lines of evidence used in support of classification: Synonymous alterations with insufficient evidence to classify as benign
GeneDx RCV000603581 SCV000729837 likely benign not specified 2017-10-23 criteria provided, single submitter clinical testing This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
Invitae RCV000228810 SCV000285202 likely benign Li-Fraumeni syndrome 2017-07-12 criteria provided, single submitter clinical testing

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