ClinVar Miner

Submissions for variant NM_000546.5(TP53):c.772G>T (p.Glu258Ter) (rs121912652)

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Total submissions: 3
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Ambry Genetics RCV000565601 SCV000675342 pathogenic Hereditary cancer-predisposing syndrome 2017-03-17 criteria provided, single submitter clinical testing Lines of evidence used in support of classification: Alterations resulting in premature truncation (e.g.reading frame shift, nonsense)
Color RCV000565601 SCV000691642 pathogenic Hereditary cancer-predisposing syndrome 2017-08-18 criteria provided, single submitter clinical testing
German Consortium for Hereditary Breast and Ovarian Cancer Center Cologne,University Hospital Cologne RCV000785351 SCV000923919 pathogenic Ovarian Neoplasms 2018-12-01 no assertion criteria provided research

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