Submissions for variant NM_000546.6(TP53):c.672+15T>C

gnomAD frequency: 0.00004  dbSNP: rs140756213

Total submissions: 6

Submitter	RCV	SCV	Clinical significance	Condition	Last evaluated	Review status	Method	Comment
Color Diagnostics, LLC DBA Color Health	RCV000583652	SCV000691608	likely benign	Hereditary cancer-predisposing syndrome	2015-09-30	criteria provided, single submitter	clinical testing
GeneDx	RCV000601851	SCV000729502	likely benign	not specified	2017-03-10	criteria provided, single submitter	clinical testing	This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
Counsyl	RCV000663274	SCV000786507	likely benign	Li-Fraumeni syndrome 1	2018-05-16	criteria provided, single submitter	clinical testing
Labcorp Genetics (formerly Invitae), Labcorp	RCV002065122	SCV002346510	likely benign	Li-Fraumeni syndrome	2024-01-28	criteria provided, single submitter	clinical testing
Genome-Nilou Lab	RCV000583652	SCV002582547	likely benign	Hereditary cancer-predisposing syndrome	2022-06-18	criteria provided, single submitter	clinical testing
Genome-Nilou Lab	RCV000663274	SCV002582849	likely benign	Li-Fraumeni syndrome 1	2022-06-18	criteria provided, single submitter	clinical testing