ClinVar Miner

Submissions for variant NM_000567.3(CRP):c.176C>T (p.Thr59Met)

gnomAD frequency: 0.00161  dbSNP: rs77832441
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Total submissions: 3
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Breakthrough Genomics, Breakthrough Genomics RCV001355473 SCV005186988 uncertain significance not provided criteria provided, single submitter not provided
Department of Pathology and Laboratory Medicine, Sinai Health System RCV001355473 SCV001550367 uncertain significance not provided no assertion criteria provided clinical testing
PreventionGenetics, part of Exact Sciences RCV003918877 SCV004733154 likely benign CRP-related disorder 2023-03-27 no assertion criteria provided clinical testing This variant is classified as likely benign based on ACMG/AMP sequence variant interpretation guidelines (Richards et al. 2015 PMID: 25741868, with internal and published modifications).

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