Submissions for variant NM_000754.4(COMT):c.408C>G (p.Leu136=)

gnomAD frequency: 0.32165  dbSNP: rs4818

Total submissions: 9

Submitter	RCV	SCV	Clinical significance	Condition	Last evaluated	Review status	Method	Comment
PreventionGenetics, part of Exact Sciences	RCV000252295	SCV000305504	benign	not specified		criteria provided, single submitter	clinical testing
GeneDx	RCV001723842	SCV001950496	benign	not provided	2021-05-04	criteria provided, single submitter	clinical testing	This variant is associated with the following publications: (PMID: 19641441, 9323320, 30218069, 25766270)
Breakthrough Genomics, Breakthrough Genomics	RCV001723842	SCV005275349	benign	not provided		criteria provided, single submitter	not provided
Bruce Budowle Laboratory, University of North Texas Health Science Center	RCV001029692	SCV001192478	drug response	Tramadol response	2018-04-28	no assertion criteria provided	research
Diagnostic Laboratory, Department of Genetics, University Medical Center Groningen	RCV000252295	SCV001740422	benign	not specified		no assertion criteria provided	clinical testing
Genome Diagnostics Laboratory, Amsterdam University Medical Center	RCV000252295	SCV001809723	benign	not specified		no assertion criteria provided	clinical testing
Joint Genome Diagnostic Labs from Nijmegen and Maastricht, Radboudumc and MUMC+	RCV000252295	SCV001952573	benign	not specified		no assertion criteria provided	clinical testing
Clinical Genetics DNA and cytogenetics Diagnostics Lab, Erasmus MC, Erasmus Medical Center	RCV000252295	SCV001968508	benign	not specified		no assertion criteria provided	clinical testing
Beijing Key Laboratory of Neuropsychopharmacology, State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology	RCV003313783	SCV002822981	uncertain risk allele	methamphetamine use disorder	2023-01-16	no assertion criteria provided	case-control