Total submissions: 1
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
Gene |
RCV000235490 | SCV000292775 | likely pathogenic | not provided | 2016-12-21 | criteria provided, single submitter | clinical testing | An variant that is likely pathogenic has been identified in the GRIN2B gene. The A652G variant has not been published as a pathogenic variant, nor has it been reported as a benign variant to our knowledge. It was not observed in approximately 6,500 individuals of European and African American ancestry in the NHLBI Exome Sequencing Project, indicating it is not a common benign variant in these populations. The A652G variant is a conservative amino acid substitution, which is not likely to impact secondary protein structure as these residues share similar properties. However, this substitution alters a highly conserved position predicted to be within the pore domain of the GRIN2B protein. In silico analysis predicts this variant is probably damaging to the protein structure/function. Additionally, targeted parental test results indicate the A652G variant is apparently de novo in this individual. Therefore, we now interpret A652G as a likely pathogenic variant; however, the possibility that it is benign cannot be excluded. |