ClinVar Miner

Submissions for variant NM_000841.4(GRM4):c.1840G>A (p.Asp614Asn)

gnomAD frequency: 0.00007  dbSNP: rs372962596
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Total submissions: 1
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Ambry Genetics RCV004396051 SCV004879887 uncertain significance not specified 2022-04-08 criteria provided, single submitter clinical testing The c.1840G>A (p.D614N) alteration is located in exon 8 (coding exon 8) of the GRM4 gene. This alteration results from a G to A substitution at nucleotide position 1840, causing the aspartic acid (D) at amino acid position 614 to be replaced by an asparagine (N). Based on insufficient or conflicting evidence, the clinical significance of this alteration remains unclear.

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