ClinVar Miner

Submissions for variant NM_000843.4(GRM6):c.2257G>A (p.Gly753Ser)

gnomAD frequency: 0.00031  dbSNP: rs79602188
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Total submissions: 3
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
CeGaT Center for Human Genetics Tuebingen RCV000416233 SCV000493395 uncertain significance not provided 2016-08-01 criteria provided, single submitter clinical testing
Invitae RCV000416233 SCV001033824 likely benign not provided 2023-12-27 criteria provided, single submitter clinical testing
PreventionGenetics, part of Exact Sciences RCV003897835 SCV004722713 likely benign GRM6-related condition 2019-09-05 criteria provided, single submitter clinical testing This variant is classified as likely benign based on ACMG/AMP sequence variant interpretation guidelines (Richards et al. 2015 PMID: 25741868, with internal and published modifications).

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