Total submissions: 1
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
Institute for Clinical Chemistry and Laboratory Medicine, |
RCV002463563 | SCV002604969 | likely pathogenic | Inherited prekallikrein deficiency | criteria provided, single submitter | clinical testing | This variant was found in an individual with no prekallikrein (PK) activity, 9% PK antigen, and a prolonged aPTT. Using sanger sequencing, we detected the variants c.689T>A p.(Ile230Asn) and c.1643G>A p.(Cys548Tyr) in KLKB1 (NM_000892.4) in compound heterozygosity (PMID: 32202057). The case was originally sequenced and published in a German PhD thesis (urn:nbn:de:hebis:30-67544). In this thesis, the author also describes a second unrelated case with PK deficiency who is compound heterozygous for the same two variants (c.689T>A and c.1643G>A). The missense variant c.689T>A has a MAF of <1% (dbSNP), and prediction tools (PolyPhen2, SIFT, PROVEAN, MutationTaster) all predicted a deleterious effect. Therefore, we classified it as likely pathogenic in accordance with ACMG guidelines . |