ClinVar Miner

Submissions for variant NM_001008387.3(REG3G):c.436T>C (p.Cys146Arg)

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Total submissions: 1
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Ambry Genetics RCV005269497 SCV005930356 uncertain significance not specified 2025-02-28 criteria provided, single submitter clinical testing The c.436T>C (p.C146R) alteration is located in exon 5 (coding exon 4) of the REG3G gene. This alteration results from a T to C substitution at nucleotide position 436, causing the cysteine (C) at amino acid position 146 to be replaced by an arginine (R). Based on insufficient or conflicting evidence, the clinical significance of this alteration remains unclear.

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