ClinVar Miner

Submissions for variant NM_001008503.2(OPRM1):c.118A>G (p.Asn40Asp) (rs1799971)

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Total submissions: 11
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
PharmGKB RCV000211310 SCV000268209 drug response naloxone response - Efficacy 2018-03-08 reviewed by expert panel curation PharmGKB Level of Evidence 2B: Annotation for a variant-drug combination with moderate evidence of an association. The association must be replicated but there may be some studies that do not show statistical significance, and/or the effect size may be small.
PharmGKB RCV000211400 SCV000268210 drug response ethanol response - Toxicity/ADR 2018-01-09 reviewed by expert panel curation PharmGKB Level of Evidence 2B: Annotation for a variant-drug combination with moderate evidence of an association. The association must be replicated but there may be some studies that do not show statistical significance, and/or the effect size may be small.
PharmGKB RCV000660781 SCV000783020 drug response alfentanil response - Dosage, Efficacy, Metabolism/PK 2018-04-20 reviewed by expert panel curation PharmGKB Level of Evidence 2B: Annotation for a variant-drug combination with moderate evidence of an association. The association must be replicated but there may be some studies that do not show statistical significance, and/or the effect size may be small.
PharmGKB RCV000660782 SCV000783021 drug response buprenorphine response - Dosage, Efficacy, Metabolism/PK 2018-04-20 reviewed by expert panel curation PharmGKB Level of Evidence 2B: Annotation for a variant-drug combination with moderate evidence of an association. The association must be replicated but there may be some studies that do not show statistical significance, and/or the effect size may be small.
PharmGKB RCV000660783 SCV000783022 drug response Drugs used in opioid dependence response - Dosage, Efficacy, Metabolism/PK 2018-04-20 reviewed by expert panel curation PharmGKB Level of Evidence 2B: Annotation for a variant-drug combination with moderate evidence of an association. The association must be replicated but there may be some studies that do not show statistical significance, and/or the effect size may be small.
PharmGKB RCV000660784 SCV000783023 drug response fentanyl response - Dosage, Efficacy, Metabolism/PK 2018-04-20 reviewed by expert panel curation PharmGKB Level of Evidence 2B: Annotation for a variant-drug combination with moderate evidence of an association. The association must be replicated but there may be some studies that do not show statistical significance, and/or the effect size may be small.
PharmGKB RCV000660785 SCV000783024 drug response heroin response - Dosage, Efficacy, Metabolism/PK 2018-04-20 reviewed by expert panel curation PharmGKB Level of Evidence 2B: Annotation for a variant-drug combination with moderate evidence of an association. The association must be replicated but there may be some studies that do not show statistical significance, and/or the effect size may be small.
PharmGKB RCV000660786 SCV000783025 drug response morphine response - Dosage, Efficacy, Metabolism/PK 2018-04-20 reviewed by expert panel curation PharmGKB Level of Evidence 2B: Annotation for a variant-drug combination with moderate evidence of an association. The association must be replicated but there may be some studies that do not show statistical significance, and/or the effect size may be small.
PharmGKB RCV000660787 SCV000783026 drug response opioids response - Dosage, Efficacy, Metabolism/PK 2018-04-20 reviewed by expert panel curation PharmGKB Level of Evidence 2B: Annotation for a variant-drug combination with moderate evidence of an association. The association must be replicated but there may be some studies that do not show statistical significance, and/or the effect size may be small.
PharmGKB RCV000660788 SCV000783027 drug response tramadol response - Dosage, Efficacy, Metabolism/PK 2018-04-20 reviewed by expert panel curation PharmGKB Level of Evidence 2B: Annotation for a variant-drug combination with moderate evidence of an association. The association must be replicated but there may be some studies that do not show statistical significance, and/or the effect size may be small.
OMIM RCV000010146 SCV000030367 uncertain significance Opioid dependence 1 2009-06-30 no assertion criteria provided literature only

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