Total submissions: 4
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
ARUP Laboratories, |
RCV001285472 | SCV001471903 | likely benign | Polycystic kidney disease, adult type | 2020-03-20 | criteria provided, single submitter | clinical testing | |
Fulgent Genetics, |
RCV001285472 | SCV002810827 | likely benign | Polycystic kidney disease, adult type | 2021-12-28 | criteria provided, single submitter | clinical testing | |
Women's Health and Genetics/Laboratory Corporation of America, |
RCV005408800 | SCV006071998 | likely benign | not specified | 2025-03-21 | criteria provided, single submitter | clinical testing | |
Department of Pathology and Laboratory Medicine, |
RCV001357396 | SCV001552862 | likely benign | not provided | no assertion criteria provided | clinical testing | The PKD1 p.Ala989= variant was not identified in the literature nor was it identified in the following databases: dbSNP, ClinVar, GeneInsight-COGR, LOVD 3.0, ADPKD Mutation Database, and PKD1-LOVD. The variant was identified in control databases in 5 of 143440 chromosomes at a frequency of 0.00004 (Genome Aggregation Database Feb 27, 2017). Breakdown of the observations by population include European in 4 of 56244 chromosomes (freq: 0.00007) and East Asian in 1 of 11448 chromosomes (freq: 0.00009), while the variant was not observed in the African, Other, Latino, Ashkenazi Jewish, Finnish, or South Asian populations. In addition we cannot be certain that data from control databases is specific to PKD1 and not from one of the six PKD1 pseudogenes. The p.Ala989= variant is not expected to have clinical significance because it does not result in a change of amino acid and is not located in a known consensus splice site. One of five in silico or computational prediction software programs (SpliceSiteFinder, MaxEntScan, NNSPLICE, GeneSplicer, HumanSpliceFinder) predict a greater than 10% difference in splicing; this is not very predictive of pathogenicity. In summary, based on the above information the clinical significance of this variant cannot be determined with certainty at this time although we would lean towards a more benign role for this variant. This variant is classified as likely benign. |