Total submissions: 1
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
ARUP Laboratories, |
RCV001285668 | SCV001472138 | uncertain significance | Polycystic kidney disease, adult type | 2020-01-30 | criteria provided, single submitter | clinical testing | The PKD1 c.9923+35G>T variant (rs376365127) is not been reported in the medical literature, but is listed as likely neutral in the Mayo ADPKD database (see link). This variant is found in the general population with an overall allele frequency of 0.021% (40/190378 alleles, including a single homozygote) in the Genome Aggregation Database. This is an intronic variant in a weakly conserved nucleotide, and computational analyses (Alamut v.2.11) predict that this variant may impact splicing by strengthening a cryptic splice acceptor site 40 nucleotides downstream of the canonical splice donor. Although most introns in the human genome are 60 nucleotides or larger (Zhang 1998), the presence of at least one canonical intron that is only 24 nucleotide in length suggests that the cryptic splice acceptor could participate in aberrant splicing. However, without functional studies the effect on splicing is unknown. Due to limited information, the clinical significance of the c.9923+35G>T variant is uncertain at this time. References: Mayo ADPKD database: http://pkdb.mayo.edu/ Zhang M. Statistical features of human exons and their flanking regions. Hum Mol Genet. 1998; 7(5):919-32. |