Total submissions: 1
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
Broad Center for Mendelian Genomics, |
RCV004556142 | SCV005045273 | likely pathogenic | Diamond-Blackfan anemia | 2024-05-13 | criteria provided, single submitter | curation | The heterozygous p.Arg121Leu variant in RPS19 was identified by our study in one individual with Diamond-Blackfan anemia. Trio exome analysis showed this variant to be de novo. This variant was absent from large population studies. Computational prediction tools and conservation analyses suggest that this variant may impact the protein, though this information is not predictive enough to determine pathogenicity. One additional likely pathogenic variant, resulting in a different amino acid change at the same position, p.Arg121His, has been reported in association with disease in the literature, slightly supporting that a change at this position may not be tolerated (PMID: 34958143). In summary, although additional studies are required to fully establish its clinical significance, this variant is likely pathogenic for autosomal dominant Diamond-Blackfan anemia. ACMG/AMP Criteria applied: PS2_Supporting, PM2_Supporting, PP3_Moderate, PM5 (Richards 2015). |