Total submissions: 1
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
Ambry Genetics | RCV002333319 | SCV002630260 | pathogenic | Diamond-Blackfan anemia | 2016-02-12 | criteria provided, single submitter | clinical testing | The c.416_423delCAGCTGCCins10 pathogenic mutation, located in coding exon 5 of the RPS19 gene, results from the deletion of 8 nucleotides and insertion of 10 nucleotides. This deletion and insertion, and subsequent frameshift, occur near the 3' terminus of RPS19 and result in the elongation of the protein by 13 amino acids. This mutation perturbs a known motif responsible for signaling and interaction with chromatin, in addition to inserting extraneous residues into the constrained environment of the complex (Lorini et al. Eur. J. Pediatr 1986.;145(3):182-4; Downey et al.Mol. Cell Proteomics 2015;14(1):162-76). In addition, since frameshifts are typically deleterious in nature, this alteration is interpreted as a disease-causing mutation (ACMG Recommendations for Standards for Interpretation and Reporting of Sequence Variations. Revision 2007. Genet Med. 2008;10:294). |