Total submissions: 1
| Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
|---|---|---|---|---|---|---|---|---|
| Department of Pathology and Laboratory Medicine, |
RCV001356098 | SCV001551168 | likely pathogenic | not provided | no assertion criteria provided | clinical testing | The TRIOBP p.Asp622Glufs*42 variant was not identified in the literature nor was it identified in dbSNP, ClinVar or in the following control databases: the 1000 Genomes Project, the NHLBI GO Exome Sequencing Project, the Exome Aggregation Consortium (August 8th 2016), or the Genome Aggregation Database (March 6, 2019, v2.1.1). The c.1866_1867del variant is predicted to cause a frameshift, which alters the protein's amino acid sequence beginning at codon 622 and leads to a premature stop codon 42 codons downstream. This alteration is then predicted to result in a truncated or absent protein and loss of function. Loss of function variants of the TRIOBP gene are an established mechanism of disease in Deafness, autosomal recessive 28 and are the type of variants expected to cause the disorder when found in the homozygous or compound heterozygous state. In summary, based on the above information the clinical significance of this variant cannot be determined with certainty at this time although we would lean towards a more pathogenic role for this variant. This variant is classified as likely pathogenic. |