ClinVar Miner

Submissions for variant NM_001039141.3(TRIOBP):c.6571C>T (p.His2191Tyr)

gnomAD frequency: 0.00635  dbSNP: rs61729063
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Total submissions: 4
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Laboratory for Molecular Medicine, Mass General Brigham Personalized Medicine RCV000217679 SCV000269912 benign not specified 2012-04-30 criteria provided, single submitter clinical testing His2191Tyr in Exon 19 of TRIOBP: This variant is not expected to have clinical s ignificance because it has been identified in 1.7% (57/3300) of African American chromosomes from a broad population by the NHLBI Exome Sequencing Project (http ://evs.gs.washington.edu/EVS; dbSNP rs61729063).
PreventionGenetics, part of Exact Sciences RCV000217679 SCV000306116 benign not specified criteria provided, single submitter clinical testing
GeneDx RCV000905230 SCV000727304 benign not provided 2019-02-26 criteria provided, single submitter clinical testing
Labcorp Genetics (formerly Invitae), Labcorp RCV000905230 SCV001049800 benign not provided 2025-01-19 criteria provided, single submitter clinical testing

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