ClinVar Miner

Submissions for variant NM_001048171.1(MUTYH):c.324C>T (p.Asp108=) (rs876660505)

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Total submissions: 4
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Ambry Genetics RCV000217949 SCV000277987 likely benign Hereditary cancer-predisposing syndrome 2015-08-24 criteria provided, single submitter clinical testing Synonymous alterations with insufficient evidence to classify as benign
Counsyl RCV000412193 SCV000487371 likely benign MYH-associated polyposis 2016-07-25 criteria provided, single submitter clinical testing
GeneDx RCV000436173 SCV000533611 likely benign not specified 2016-11-02 criteria provided, single submitter clinical testing This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
Invitae RCV000412193 SCV001055666 likely benign MYH-associated polyposis 2020-10-03 criteria provided, single submitter clinical testing

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