ClinVar Miner

Submissions for variant NM_001080477.4(TENM3):c.3400G>A (p.Gly1134Arg)

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Total submissions: 2
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Ambry Genetics RCV003368462 SCV004056252 uncertain significance Inborn genetic diseases 2023-06-22 criteria provided, single submitter clinical testing The c.3400G>A (p.G1134R) alteration is located in exon 18 (coding exon 18) of the TENM3 gene. This alteration results from a G to A substitution at nucleotide position 3400, causing the glycine (G) at amino acid position 1134 to be replaced by an arginine (R). Based on insufficient or conflicting evidence, the clinical significance of this alteration remains unclear.
Center for Computational Biology & Bioinformatics, University of California, San Diego RCV004572953 SCV005049969 uncertain significance Meniere disease 2024-06-03 no assertion criteria provided research

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