Total submissions: 1
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
New York Genome Center | RCV002275567 | SCV002564174 | uncertain significance | Imerslund-Grasbeck syndrome type 1; Proteinuria, chronic benign | 2021-10-01 | criteria provided, single submitter | clinical testing | The inherited heterozygous missense variant c.3605C>T (p.Ala1202Val) identified in exon 25 (of 67) of the CUBN gene has not beenreported in affected individuals the literature. The variant is absent in the gnomAD(v3) database suggesting it is not a common benign variant in the populations represented in that database. Two heterozygous missense variants resulting in a different amino acid change (p.Ala1202Ser and p.Ala1202Thr) at this codon have been reported as variant of uncertain significance and/or likely benign in ClinVar (Variation ID: 877581 and 299487). The affected residue (Ala1202) is not conserved.In silico tools provide conflicting predictions about pathogenicity of this variant (CADD score = 22.00, REVEL score = 0.100). Due to the lack of compelling evidencefor its pathogenicity, the heterozygous c.3605C>T (p.Ala1202Val) missense variant identified in the CUBN gene is reported as a Variant of Uncertain Significance. |