Submissions for variant NM_001105206.3(LAMA4):c.280G>A (p.Gly94Ser)

gnomAD frequency: 0.01717  dbSNP: rs35349917

Total submissions: 11

Submitter	RCV	SCV	Clinical significance	Condition	Last evaluated	Review status	Method	Comment
Biesecker Lab/Clinical Genomics Section, National Institutes of Health	RCV000037356	SCV000051555	benign	not specified	2013-06-24	criteria provided, single submitter	research
Laboratory for Molecular Medicine, Mass General Brigham Personalized Medicine	RCV000037356	SCV000061013	benign	not specified	2012-02-09	criteria provided, single submitter	clinical testing	Benign based on high population frequency
GeneDx	RCV000037356	SCV000170047	benign	not specified	2014-01-15	criteria provided, single submitter	clinical testing	This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
Invitae	RCV000472707	SCV000556719	benign	Dilated cardiomyopathy 1JJ	2024-01-31	criteria provided, single submitter	clinical testing
CHEO Genetics Diagnostic Laboratory, Children's Hospital of Eastern Ontario	RCV000769211	SCV000900587	benign	Cardiomyopathy	2016-04-07	criteria provided, single submitter	clinical testing
ARUP Laboratories, Molecular Genetics and Genomics, ARUP Laboratories	RCV000472707	SCV001471590	benign	Dilated cardiomyopathy 1JJ	2023-10-16	criteria provided, single submitter	clinical testing
Women's Health and Genetics/Laboratory Corporation of America, LabCorp	RCV000037356	SCV003929153	likely benign	not specified	2023-04-17	criteria provided, single submitter	clinical testing
Clinical Genetics, Academic Medical Center	RCV000037356	SCV001919936	benign	not specified		no assertion criteria provided	clinical testing
Genome Diagnostics Laboratory, University Medical Center Utrecht	RCV000037356	SCV001932047	benign	not specified		no assertion criteria provided	clinical testing
Joint Genome Diagnostic Labs from Nijmegen and Maastricht, Radboudumc and MUMC+	RCV000037356	SCV001959220	benign	not specified		no assertion criteria provided	clinical testing
Clinical Genetics DNA and cytogenetics Diagnostics Lab, Erasmus MC, Erasmus Medical Center	RCV000037356	SCV001974861	benign	not specified		no assertion criteria provided	clinical testing