ClinVar Miner

Submissions for variant NM_001128425.1(MUTYH):c.972G>A (p.Ser324=) (rs771683103)

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Total submissions: 5
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Invitae RCV000528615 SCV000639369 likely benign MYH-associated polyposis 2017-10-18 criteria provided, single submitter clinical testing
Ambry Genetics RCV000575298 SCV000662602 likely benign Hereditary cancer-predisposing syndrome 2015-10-20 criteria provided, single submitter clinical testing Synonymous alterations with insufficient evidence to classify as benign
Color Health, Inc RCV000575298 SCV000690618 likely benign Hereditary cancer-predisposing syndrome 2017-02-21 criteria provided, single submitter clinical testing
GeneDx RCV000609555 SCV000722244 likely benign not specified 2017-08-22 criteria provided, single submitter clinical testing This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
Women's Health and Genetics/Laboratory Corporation of America, LabCorp RCV000609555 SCV001361131 likely benign not specified 2019-10-31 criteria provided, single submitter clinical testing

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