Total submissions: 1
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
Illumina Laboratory Services, |
RCV001795585 | SCV002034802 | uncertain significance | Complex neurodevelopmental disorder | 2021-09-03 | criteria provided, single submitter | clinical testing | The GRIN2A c.146G>A (p.Arg49His) variant is a missense variant. A literature search was conducted for the gene, cDNA change, and amino acid change. No publications were identified through that search. The p.Arg49His variant is reported at a frequency of 0.000009 in the European (non-Finnish) population of the Genome Aggregation Database (version 2.1.1). This frequency is based on one allele in a region of good sequencing coverage, so the variant is presumed to be rare. Strehlow et al. (2018) reported that disease-causing missense variants tend to cluster in functionally important domains near the center of the gene, namely the S1 and S2 ligand binding domains as well as the M1-M4 transmembrane domains and linker regions. This variant is located within a zinc binding domain near the N-terminal, and in silico algorithms do not consistently predict this variant will impact protein structure. Based on the limited evidence available, the p.Arg49His variant is classified as a variant of uncertain significance for GRIN2A-complex neurodevelopmental disorder. |