ClinVar Miner

Submissions for variant NM_001139.3(ALOX12B):c.1349G>A (p.Gly450Glu)

dbSNP: rs772257172
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Total submissions: 2
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Women's Health and Genetics/Laboratory Corporation of America, LabCorp RCV004770006 SCV005380461 uncertain significance not specified 2024-08-21 criteria provided, single submitter clinical testing Variant summary: ALOX12B c.1349G>A (p.Gly450Glu) results in a non-conservative amino acid change located in the Lipoxygenase, C-terminal domain (IPR013819) of the encoded protein sequence. Five of five in-silico tools predict a damaging effect of the variant on protein function. The frequency data for this variant in gnomAD is considered unreliable, as metrics indicate poor data quality at this position. c.1349G>A has been reported in the literature in at-least one individual affected with Autosomal recessive congenital ichthyosis (example: Hotz_2021). These data do not allow any conclusion about variant significance. To our knowledge, no experimental evidence demonstrating an impact on protein function has been reported. The following publication has been ascertained in the context of this evaluation (PMID: 33435499). ClinVar contains an entry for this variant (Variation ID: 995744). Based on the evidence outlined above, the variant was classified as uncertain significance.
Institute for Human Genetics, University Medical Center Freiburg RCV001289953 SCV001477960 pathogenic Autosomal recessive congenital ichthyosis 2 2021-01-07 no assertion criteria provided clinical testing

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