ClinVar Miner

Submissions for variant NM_001142571.2(RAD51D):c.681G>A (p.Ser227=) (rs749859221)

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Total submissions: 5
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Ambry Genetics RCV000219817 SCV000275008 likely benign Hereditary cancer-predisposing syndrome 2015-04-07 criteria provided, single submitter clinical testing
Invitae RCV000228708 SCV000287718 likely benign Breast-ovarian cancer, familial 4 2019-12-31 criteria provided, single submitter clinical testing
GeneDx RCV000609586 SCV000732259 likely benign not specified 2017-03-15 criteria provided, single submitter clinical testing This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
Color RCV000219817 SCV001359186 likely benign Hereditary cancer-predisposing syndrome 2020-01-27 criteria provided, single submitter clinical testing
True Health Diagnostics RCV000219817 SCV000805307 likely benign Hereditary cancer-predisposing syndrome 2018-05-08 no assertion criteria provided clinical testing

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