Total submissions: 1
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
Illumina Laboratory Services, |
RCV003315127 | SCV004014730 | likely pathogenic | Wiedemann-Steiner syndrome | 2023-04-19 | criteria provided, single submitter | clinical testing | The KMT2A c.9684del (p.Leu3229TyrfsTer27) variant causes a shift in the protein reading frame that is predicted to result in premature termination of the protein. Loss of normal protein function through either protein truncation or nonsense-mediated mRNA decay is expected. To our knowledge, this variant has not been reported in the peer-reviewed literature. This variant is not observed in version 2.1.1 or version 3.1.2 of the Genome Aggregation Database. Based on the available evidence, the c.9684del (p.Leu3229TyrfsTer27) variant is classified as likely pathogenic for Wiedemann-Steiner syndrome. |