Total submissions: 1
| Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
|---|---|---|---|---|---|---|---|---|
| King Laboratory, |
RCV003155588 | SCV003844185 | likely pathogenic | Autosomal recessive nonsyndromic hearing loss 8 | 2023-02-28 | criteria provided, single submitter | research | This variant occurred in compound heterozygosity with a TMPRSS3 frameshift variant in a patient with bilateral sensorineural hearing loss of onset <18 years, in a study of pediatric hearing loss conducted by the King Laboratory (Carlson RJ et al. JAMA-OtoHNS 2023). The patient’s family has no other history of hearing loss. This variant is a missense at a highly conserved site in the peptidase S1 domain of the TMPRSS3 protein and is predicted to be damaging by multiple in-silico tools. As of January 2023, this variant has not been reported to ClinVar and is not found on gnomAD. Based on consistently predicted functional effect, compound heterozygosity with a loss-of-function variant, and goodness of fit of genotype to phenotype, we conclude that this variant is likely pathogenic. |