Total submissions: 1
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
Broad Center for Mendelian Genomics, |
RCV003226063 | SCV003922160 | uncertain significance | Myopathy, myofibrillar, 9, with early respiratory failure | 2023-05-02 | criteria provided, single submitter | curation | The heterozygous p.Asn33239ThrfsTer18 variant in TTN was identified by our study in one individual with myofibrillar myopathy. The p.Asn33239ThrfsTer18 variant in TTN has not been previously reported in individuals with myofibrillar myopathy-9 with early respiratory failure. This variant was absent from large population studies. This variant is predicted to cause a frameshift, which alters the protein’s amino acid sequence beginning at position 33239 and leads to a premature termination codon 18 amino acids downstream. This alteration is then predicted to lead to a truncated or absent protein. It is of note that heterozygous loss of function of TTN in autosomal dominant myofibrillar myopathy-9 with early respiratory failure has not yet been established based on the criteria laid out in Tayoun et al., 2018 (PMID: 30192042). In summary, the clinical significance of the p.Asn33239ThrfsTer18 variant in TTN is uncertain. ACMG/AMP Criteria applied: PM2_Supporting (Richards 2015). |