Total submissions: 1
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
Laboratory for Molecular Medicine, |
RCV000825476 | SCV000966778 | likely pathogenic | Primary dilated cardiomyopathy | 2019-05-14 | criteria provided, single submitter | clinical testing | The p.Asp88Glu (c.264T>A) variant in TNNT2 has been identified as a de novo change in 1 individual with infantile-onset DCM (LMM data), but was absent from large population studies. Additionally, a different variant resulting in the same amino acid change, c.264T>G, has been identified as a de novo change in another individual with infantile-onset DCM (LMM data). Computational prediction tools and conservation analysis suggest that the p.Asp88Glu variant may impact the protein, though this information is not predictive enough to determine pathogenicity. In addition, this variant is located in the last three bases of the exon, which is part of the 5’ splice region. While computational tools do not predict an impact on splicing, these tools may not accurately predict biological function. In summary, although additional studies are required to fully establish its clinical significance, the p.Asp88Glu (c.264T>A) variant meets criteria to be classified as likely pathogenic for autosomal dominant dilated cardiomyopathy. ACMG/AMP Criteria applied: PM2, PM6, PP3, PS1_Supporting. |