Submissions for variant NM_001276345.2(TNNT2):c.68-8A>G

gnomAD frequency: 0.00864  dbSNP: rs115805892

Total submissions: 13

Submitter	RCV	SCV	Clinical significance	Condition	Last evaluated	Review status	Method	Comment
Laboratory for Molecular Medicine, Mass General Brigham Personalized Medicine	RCV000036313	SCV000059965	benign	not specified	2011-12-23	criteria provided, single submitter	clinical testing
Invitae	RCV000463859	SCV000554792	benign	Hypertrophic cardiomyopathy 2; Dilated cardiomyopathy 1D; Cardiomyopathy, familial restrictive, 3	2023-12-11	criteria provided, single submitter	clinical testing
Color Diagnostics, LLC DBA Color Health	RCV000771839	SCV000904553	benign	Cardiomyopathy	2018-03-20	criteria provided, single submitter	clinical testing
GeneDx	RCV001529209	SCV001939262	benign	not provided	2015-03-03	criteria provided, single submitter	clinical testing
ARUP Laboratories, Molecular Genetics and Genomics, ARUP Laboratories	RCV001529209	SCV002049810	benign	not provided	2021-11-09	criteria provided, single submitter	clinical testing
Genome-Nilou Lab	RCV003445098	SCV004173852	benign	Dilated cardiomyopathy 1D	2023-04-11	criteria provided, single submitter	clinical testing
Genome-Nilou Lab	RCV003445099	SCV004173854	benign	Cardiomyopathy, familial restrictive, 3	2023-04-11	criteria provided, single submitter	clinical testing
Genome-Nilou Lab	RCV003445097	SCV004173855	benign	Hypertrophic cardiomyopathy 2	2023-04-11	criteria provided, single submitter	clinical testing
PreventionGenetics, part of Exact Sciences	RCV003952414	SCV004771956	benign	TNNT2-related condition	2019-04-15	criteria provided, single submitter	clinical testing	This variant is classified as benign based on ACMG/AMP sequence variant interpretation guidelines (Richards et al. 2015 PMID: 25741868, with internal and published modifications).
Diagnostic Laboratory, Department of Genetics, University Medical Center Groningen	RCV001529209	SCV001742286	likely benign	not provided		no assertion criteria provided	clinical testing
Clinical Genetics, Academic Medical Center	RCV000036313	SCV001919313	benign	not specified		no assertion criteria provided	clinical testing
Joint Genome Diagnostic Labs from Nijmegen and Maastricht, Radboudumc and MUMC+	RCV000036313	SCV001957646	benign	not specified		no assertion criteria provided	clinical testing
Clinical Genetics DNA and cytogenetics Diagnostics Lab, Erasmus MC, Erasmus Medical Center	RCV000036313	SCV001968812	benign	not specified		no assertion criteria provided	clinical testing