Total submissions: 1
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
Department of Pediatrics, |
RCV003224820 | SCV002588463 | pathogenic | Developmental and epileptic encephalopathy, 61 | 2022-10-31 | criteria provided, single submitter | clinical testing | The homozygous Ser905Phe variant in ADAM22 was found in a patient with with early-onset focal epilepsy, slightly delayed psychomotor development and behavioural disorder. The variant is absent in gnomAD database. In vitro functional studies showed that Ser905Phe mutant protein has reduced binding capacity to a family of membrane-associated guanylate kinases compared to wild-type protein and represents a partial loss-of-function variant leading to milder phenotype. The Ser905Phe variant meets our criteria to be classified as pathogenic based upon segregation studies, absence from controls, and functional evidence. |