Total submissions: 4
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
Genetics Laboratory, |
RCV001420327 | SCV001622747 | likely pathogenic | See cases | 2021-04-26 | criteria provided, single submitter | clinical testing | PM1_moderate;PM2_supporting;PM5_moderate;PM6_moderate;PP2_supporting;PP3_supporting |
Mendelics | RCV002246382 | SCV002519591 | pathogenic | DYRK1A-related intellectual disability syndrome | 2022-05-04 | criteria provided, single submitter | clinical testing | |
Al Jalila Children’s Genomics Center, |
RCV004798912 | SCV005420649 | likely pathogenic | Intellectual disability | 2024-10-04 | criteria provided, single submitter | research | PM6,PM2,PP3,PM5 |
Labcorp Genetics |
RCV002246382 | SCV005831993 | uncertain significance | DYRK1A-related intellectual disability syndrome | 2024-04-17 | criteria provided, single submitter | clinical testing | This sequence change replaces glycine, which is neutral and non-polar, with arginine, which is basic and polar, at codon 348 of the DYRK1A protein (p.Gly348Arg). This variant is not present in population databases (gnomAD no frequency). This missense change has been observed in individuals with clinical features of DYRK1A-related conditions (PMID: 31164858, 34374989; Invitae). ClinVar contains an entry for this variant (Variation ID: 1098405). Advanced modeling of protein sequence and biophysical properties (such as structural, functional, and spatial information, amino acid conservation, physicochemical variation, residue mobility, and thermodynamic stability) performed at Invitae indicates that this missense variant is expected to disrupt DYRK1A protein function with a positive predictive value of 80%. In summary, the available evidence is currently insufficient to determine the role of this variant in disease. Therefore, it has been classified as a Variant of Uncertain Significance. |