Total submissions: 2
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
Yatsenko Laboratory, |
RCV003149073 | SCV003836548 | likely benign | Spermatogenic failure 25 | 2022-12-30 | criteria provided, single submitter | research | |
Ambry Genetics | RCV004246161 | SCV003956972 | uncertain significance | not specified | 2023-03-21 | criteria provided, single submitter | clinical testing | The c.1292C>T (p.P431L) alteration is located in exon 1 (coding exon 1) of the TEX15 gene. This alteration results from a C to T substitution at nucleotide position 1292, causing the proline (P) at amino acid position 431 to be replaced by a leucine (L). Based on insufficient or conflicting evidence, the clinical significance of this alteration remains unclear. |