Total submissions: 1
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
Women's Health and Genetics/Laboratory Corporation of America, |
RCV003230962 | SCV003929211 | likely pathogenic | Brittle cornea syndrome 1 | 2023-04-04 | criteria provided, single submitter | clinical testing | Variant summary: ZNF469 c.5613_5622del10 (p.Arg1871SerfsX25) results in a premature termination codon and is predicted to cause a truncation of the encoded protein. Although the variant is not predicted to cause absence of the protein through nonsense mediated decay, the variant disrupts the last ~2000 amino acids in the protein sequence, which is greater than half of the total protein. Truncations downstream of this position have been classified as pathogenic within ClinVar (e.g. c.7554del [p.Ser2519Alafs], c.8350C>T [p.Arg2784Ter]). The variant was absent in 151752 control chromosomes (gnomAD). To our knowledge, no occurrence of c.5613_5622del10 in individuals affected with Brittle Cornea Syndrome 1 and no experimental evidence demonstrating its impact on protein function have been reported. No clinical diagnostic laboratories have submitted clinical-significance assessments for this variant to ClinVar after 2014. Based on the evidence outlined above, the variant was classified as likely pathogenic. |