Total submissions: 1
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
Molecular Genetics, |
RCV003994686 | SCV004812634 | uncertain significance | Blau syndrome | 2023-08-01 | criteria provided, single submitter | clinical testing | This sequence change in NOD2 is predicted to replace phenylalanine with leucine at codon 47, p.(Phe47Leu). The phenylalanine residue is weakly conserved (100 vertebrates, UCSC), and is located in CARD1 domain. There is a small physicochemical difference between phenylalanine and leucine. The highest population minor allele frequency in the population database gnomAD v3.1 is 0.001% (1/68022 alleles) in the European non-Finnish population. To our knowledge, this variant has not been previously reported in the relevant scientific literature or databases. Computational evidence predicts a benign effect for the missense substitution (REVEL = 0.039). Based on the classification scheme RMH Modified ACMG/AMP Guidelines v1.6.1, this variant is classified as a VARIANT OF UNCERTAIN SIGNIFICANCE. Following criteria are met: PM2_Supporting, BP4 |