Total submissions: 2
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
Institute of Human Genetics, |
RCV002468849 | SCV002765025 | uncertain significance | Intellectual disability, autosomal dominant 13 | 2022-12-09 | criteria provided, single submitter | clinical testing | _x000D_ Criteria applied: PM2_SUP, PP2, PP3 |
Labcorp Genetics |
RCV003528403 | SCV004267867 | uncertain significance | Charcot-Marie-Tooth disease axonal type 2O | 2024-01-28 | criteria provided, single submitter | clinical testing | This sequence change replaces arginine, which is basic and polar, with histidine, which is basic and polar, at codon 3413 of the DYNC1H1 protein (p.Arg3413His). This variant is present in population databases (rs776130043, gnomAD 0.004%). This variant has not been reported in the literature in individuals affected with DYNC1H1-related conditions. ClinVar contains an entry for this variant (Variation ID: 1804111). Advanced modeling of protein sequence and biophysical properties (such as structural, functional, and spatial information, amino acid conservation, physicochemical variation, residue mobility, and thermodynamic stability) performed at Invitae indicates that this missense variant is expected to disrupt DYNC1H1 protein function with a positive predictive value of 95%. In summary, the available evidence is currently insufficient to determine the role of this variant in disease. Therefore, it has been classified as a Variant of Uncertain Significance. |