Total submissions: 1
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
Neuberg Centre For Genomic Medicine, |
RCV003338024 | SCV004048566 | likely pathogenic | Intellectual disability, autosomal dominant 13 | criteria provided, single submitter | clinical testing | The missense variant p.P1356L in DYNC1H1 (NM_001376.5) has not been reported previously as a pathogenic variant nor as a benign variant, to our knowledge. The p.P1356L variant is novel (not in any individuals) in gnomAD Exomes and is novel (not in any individuals) in 1000 Genomes. There is a moderate physicochemical difference between proline and leucine. The p.P1356L missense variant is predicted to be damaging by both SIFT and PolyPhen2. The proline residue at codon 1356 of DYNC1H1 is conserved in all mammalian species. The nucleotide c.4067 in DYNC1H1 is predicted conserved by GERP++ and PhyloP across 100 vertebrates. The above variant was not detected in his parents and hence is a de novo variant. For these reasons, this variant has been classified as Likely Pathogenic. The observed variant was not detected in father or mother. |