ClinVar Miner

Submissions for variant NM_001378615.1(CC2D2A):c.1850T>C (p.Val617Ala)

dbSNP: rs1718226237
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Total submissions: 1
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Invitae RCV001248185 SCV001421654 uncertain significance Familial aplasia of the vermis; Meckel-Gruber syndrome 2021-06-22 criteria provided, single submitter clinical testing In summary, the available evidence is currently insufficient to determine the role of this variant in disease. Therefore, it has been classified as a Variant of Uncertain Significance. Algorithms developed to predict the effect of missense changes on protein structure and function output the following: SIFT: "Tolerated"; PolyPhen-2: "Benign"; Align-GVGD: "Class C0". The alanine amino acid residue is found in multiple mammalian species, suggesting that this missense change does not adversely affect protein function. These predictions have not been confirmed by published functional studies and their clinical significance is uncertain. This variant has not been reported in the literature in individuals with CC2D2A-related conditions. This variant is not present in population databases (ExAC no frequency). This sequence change replaces valine with alanine at codon 617 of the CC2D2A protein (p.Val617Ala). The valine residue is weakly conserved and there is a small physicochemical difference between valine and alanine.

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