Total submissions: 3
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
Victorian Clinical Genetics Services, |
RCV002306289 | SCV005086779 | pathogenic | Developmental and epileptic encephalopathy 108 | 2023-12-21 | criteria provided, single submitter | clinical testing | Based on the classification scheme VCGS_Germline_v1.3.4, this variant is classified as Pathogenic. Following criteria are met: 0101 - Gain of function is a known mechanism of disease in this gene and is associated with developmental and epileptic encephalopathy 108 (MIM#620115) (PMID: 34185323). (I) 0107 - This gene is associated with autosomal dominant disease. (I) 0200 - Variant is predicted to result in a missense amino acid change from glycine to serine. (I) 0251 - This variant is heterozygous. (I) 0301 - Variant is absent from gnomAD (both v2 and v3). (SP) 0502 - Missense variant with conflicting in silico predictions and high conservation. (I) 0600 - Variant is located in the annotated serine/threonine kinase (STK) domain (PMID: 34185323). (I) 0801 - This variant has strong previous evidence of pathogenicity in unrelated individuals. It has been detected in individuals with developmental delay and epileptic encephalopathy, and shown to be de novo in at least two families (PMIDs: 34185323, 35095415). (SP) 1203 - This variant has been shown to be de novo in the proband (parental status confirmed). (SP) Legend: (SP) - Supporting pathogenic, (I) - Information, (SB) - Supporting benign |
Institute of Human Genetics, |
RCV002306289 | SCV005423772 | pathogenic | Developmental and epileptic encephalopathy 108 | 2024-11-21 | criteria provided, single submitter | clinical testing | Criteria applied: PS2_VSTR,PS3_SUP,PS4_MOD,PM2_SUP,PP2,PP3 |
OMIM | RCV002306289 | SCV002600207 | pathogenic | Developmental and epileptic encephalopathy 108 | 2022-11-10 | no assertion criteria provided | literature only |