Total submissions: 1
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
Laboratory for Molecular Medicine, |
RCV000037187 | SCV000060844 | likely pathogenic | Hypohidrotic X-linked ectodermal dysplasia | 2011-07-22 | criteria provided, single submitter | clinical testing | The Trp274Cys variant in EDA has not been reported in the literature nor previou sly identified by our laboratory. However, different amino acid changes at the s ame position (Trp274Gly, Trp274Arg) have been identified in 3 individuals with X -linked hypohidrotic ectodermal dysplasia (Paakkonen 2001, Schneider 2001, Cluze au 2011). In addition, this residue is conserved across species and computation al analyses (PolyPhen2, SIFT, AlignGVGD) suggest that the Trp274Cys variant may impact the protein. The change to a Cysteine at position 274 is likely to create an equal or greater impact to the protein than the other two missense mutations making it likely that this mutation is also pathogenic. In summary, this varia nt is likely to be pathogenic. |