ClinVar Miner

Submissions for variant NM_001709.5(BDNF):c.196G>A (p.Val66Met)

gnomAD frequency: 0.14533  dbSNP: rs6265
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Total submissions: 5
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Laboratory for Molecular Medicine, Mass General Brigham Personalized Medicine RCV000155463 SCV000205154 benign not specified 2013-06-18 criteria provided, single submitter clinical testing Benign with respect to pulmonary disease based on high population frequency, Th is variant has been proposed to be associated with a rnage of psychiatric manife stations though the data is not solid and more recent meta-analyses argue agains t a risk effect.
PreventionGenetics, part of Exact Sciences RCV000155463 SCV000316419 benign not specified criteria provided, single submitter clinical testing
Labcorp Genetics (formerly Invitae), Labcorp RCV002054446 SCV002355196 benign not provided 2024-01-31 criteria provided, single submitter clinical testing
Breakthrough Genomics, Breakthrough Genomics RCV002054446 SCV005323018 benign not provided criteria provided, single submitter not provided
OMIM RCV000019267 SCV000039555 risk factor Memory impairment, susceptibility to 2022-12-13 no assertion criteria provided literature only

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