Total submissions: 2
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
Clin |
RCV003408115 | SCV004123211 | likely benign | Hereditary thrombocytopenia and hematologic cancer predisposition syndrome | 2023-11-13 | reviewed by expert panel | curation | The NM_001754.5(RUNX1):c.59-12C>A variant is intronic and is located upstream to exon 3. The MAF of this variant is 0.00001613. However, in the East Asian subpopulation of the gnomAD v2.1.1 cohort, MAF is 0.0002190 (0.02190%, 4/248018 alleles), which is between 0.00015 (0.015%) and 0.0015 (0.15%) (BS1). In addition, splicing algorithms predicted no effect on splicing (SpliceAI score 0.08 < 0.20) (BP4) and evolutionary conservation prediction algorithms predict the site as not being conserved (PhyloP100way (GRCh38/hg38) score 0.368 < 2.0) (BP7). To our knowledge, this variant has not been found in patients with FPD/AML phenotype and no functional studies are available. In summary, this variant meets the criteria to be classified as likely benign. ACMG/AMP criteria applied, as specified by the Myeloid Malignancy Variant Curation Expert Panel for RUNX1: BS1, BP4, and BP7. |
Labcorp Genetics |
RCV002111461 | SCV002390671 | likely benign | Hereditary thrombocytopenia and hematological cancer predisposition syndrome associated with RUNX1 | 2023-09-04 | criteria provided, single submitter | clinical testing |