ClinVar Miner

Submissions for variant NM_002087.3(GRN):c.264+7G>A (rs60100877)

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Total submissions: 10
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
EGL Genetic Diagnostics, Eurofins Clinical Diagnostics RCV000177147 SCV000228978 likely benign not specified 2014-10-28 criteria provided, single submitter clinical testing
PreventionGenetics,PreventionGenetics RCV000177147 SCV000308700 benign not specified criteria provided, single submitter clinical testing
Illumina Clinical Services Laboratory,Illumina RCV000576305 SCV000403340 likely benign Grn-related frontotemporal lobar degeneration with Tdp43 inclusions 2017-04-27 criteria provided, single submitter clinical testing This variant was observed as part of a predisposition screen in an ostensibly healthy population. A literature search was performed for the gene, cDNA change, and amino acid change (where applicable). No publications were found based on this search. Allele frequency data from public databases allowed determination this variant is unlikely to cause disease. Therefore, this variant is classified as likely benign.
CeGaT Praxis fuer Humangenetik Tuebingen RCV000513109 SCV000608819 likely benign not provided 2020-02-01 criteria provided, single submitter clinical testing
Athena Diagnostics Inc RCV000576305 SCV000677378 benign Grn-related frontotemporal lobar degeneration with Tdp43 inclusions 2017-06-23 criteria provided, single submitter clinical testing
Invitae RCV001086378 SCV000772101 benign Grn-related frontotemporal lobar degeneration with Tdp43 inclusions; Ceroid lipofuscinosis, neuronal, 11 2019-12-31 criteria provided, single submitter clinical testing
GeneDx RCV000513109 SCV001819462 likely benign not provided 2020-01-22 criteria provided, single submitter clinical testing
Mayo Clinic Laboratories, Mayo Clinic RCV000513109 SCV000801379 likely benign not provided 2017-06-07 no assertion criteria provided clinical testing
Genome Diagnostics Laboratory, Amsterdam University Medical Center RCV000513109 SCV001806997 likely benign not provided no assertion criteria provided clinical testing
Clinical Genetics,Academic Medical Center RCV000177147 SCV001919084 benign not specified no assertion criteria provided clinical testing

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