Submissions for variant NM_002087.4(GRN):c.264+7G>A

gnomAD frequency: 0.00548  dbSNP: rs60100877

Total submissions: 12

Submitter	RCV	SCV	Clinical significance	Condition	Last evaluated	Review status	Method	Comment
Eurofins Ntd Llc (ga)	RCV000177147	SCV000228978	likely benign	not specified	2014-10-28	criteria provided, single submitter	clinical testing
PreventionGenetics, part of Exact Sciences	RCV000177147	SCV000308700	benign	not specified		criteria provided, single submitter	clinical testing
Illumina Laboratory Services, Illumina	RCV000576305	SCV000403340	likely benign	GRN-related frontotemporal lobar degeneration with Tdp43 inclusions	2017-04-27	criteria provided, single submitter	clinical testing	This variant was observed as part of a predisposition screen in an ostensibly healthy population. A literature search was performed for the gene, cDNA change, and amino acid change (where applicable). No publications were found based on this search. Allele frequency data from public databases allowed determination this variant is unlikely to cause disease. Therefore, this variant is classified as likely benign.
CeGaT Center for Human Genetics Tuebingen	RCV000513109	SCV000608819	likely benign	not provided	2024-07-01	criteria provided, single submitter	clinical testing	GRN: BP4, BS2
Athena Diagnostics	RCV000576305	SCV000677378	benign	GRN-related frontotemporal lobar degeneration with Tdp43 inclusions	2017-06-23	criteria provided, single submitter	clinical testing
Labcorp Genetics (formerly Invitae), Labcorp	RCV001086378	SCV000772101	benign	GRN-related frontotemporal lobar degeneration with Tdp43 inclusions; Neuronal ceroid lipofuscinosis 11	2024-01-30	criteria provided, single submitter	clinical testing
GeneDx	RCV000513109	SCV001819462	likely benign	not provided	2020-01-22	criteria provided, single submitter	clinical testing
Breakthrough Genomics, Breakthrough Genomics	RCV000513109	SCV005212866	likely benign	not provided		criteria provided, single submitter	not provided
Mayo Clinic Laboratories, Mayo Clinic	RCV000513109	SCV000801379	likely benign	not provided	2017-06-07	no assertion criteria provided	clinical testing
Genome Diagnostics Laboratory, Amsterdam University Medical Center	RCV000513109	SCV001806997	likely benign	not provided		no assertion criteria provided	clinical testing
Clinical Genetics, Academic Medical Center	RCV000177147	SCV001919084	benign	not specified		no assertion criteria provided	clinical testing
Clinical Genetics DNA and cytogenetics Diagnostics Lab, Erasmus MC, Erasmus Medical Center	RCV000513109	SCV001974821	likely benign	not provided		no assertion criteria provided	clinical testing