ClinVar Miner

Submissions for variant NM_002087.4(GRN):c.903G>A (p.Ser301=) (rs63750142)

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Total submissions: 5
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Athena Diagnostics Inc RCV000516232 SCV000613584 benign not specified 2016-09-29 criteria provided, single submitter clinical testing
Ambry Genetics RCV000720880 SCV000851764 likely benign Seizures 2017-05-25 criteria provided, single submitter clinical testing
Invitae RCV001086995 SCV001016414 likely benign Grn-related frontotemporal lobar degeneration with Tdp43 inclusions; Ceroid lipofuscinosis, neuronal, 11 2019-12-31 criteria provided, single submitter clinical testing
Illumina Clinical Services Laboratory,Illumina RCV001128036 SCV001287427 likely benign Grn-related frontotemporal lobar degeneration with Tdp43 inclusions 2017-04-27 criteria provided, single submitter clinical testing This variant was observed as part of a predisposition screen in an ostensibly healthy population. A literature search was performed for the gene, cDNA change, and amino acid change (where applicable). Publications were found based on this search. The evidence from the literature, in combination with allele frequency data from public databases where available, was sufficient to determine this variant is unlikely to cause disease. Therefore, this variant is classified as likely benign.
VIB Department of Molecular Genetics, University of Antwerp RCV000084462 SCV000116598 not provided not provided no assertion provided not provided

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