Total submissions: 1
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
Labcorp Genetics |
RCV000685738 | SCV000813232 | pathogenic | Danon disease | 2018-01-28 | criteria provided, single submitter | clinical testing | This sequence change creates a premature translational stop signal (p.Ser157*) in the LAMP2 gene. It is expected to result in an absent or disrupted protein product. This variant is not present in population databases (ExAC no frequency). This variant has not been reported in the literature in individuals with LAMP2-related disease. Algorithms developed to predict the effect of sequence changes on RNA splicing suggest that this variant may create or strengthen a splice site, but this prediction has not been confirmed by published transcriptional studies. A different variant (c.470C>G ) giving rise to the same protein effect observed here (p.Ser157*) has been reported to segregate with Danon disease in a single family (PMID: 15792868), indicating that this residue may be critical for protein function. Loss-of-function variants in LAMP2 are known to be pathogenic (PMID: 21415759). For these reasons, this variant has been classified as Pathogenic. |