ClinVar Miner

Submissions for variant NM_002524.5(NRAS):c.450+18G>T

gnomAD frequency: 0.00001  dbSNP: rs766994734
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Total submissions: 2
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
GeneDx RCV000422469 SCV000513954 benign not provided 2016-11-22 criteria provided, single submitter clinical testing This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
Labcorp Genetics (formerly Invitae), Labcorp RCV002061449 SCV002369865 likely benign RASopathy 2024-01-22 criteria provided, single submitter clinical testing

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